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Both medication classes may cause gastrointestinal side effects including nausea, diarrhoea, and abdominal discomfort, which may overlap during concurrent use

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10.1186/1710-1492-10-43 215 JiaL.XiaoL.FuY.ShaoZ.JingZ.YuanJ.et al

Quick Answer: Nausea affects approximately 24-30% of patients taking tirzepatide weight loss shots and typically improves within several weeks as the body adjusts to the medication