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The discovery led Palatin Technologies to pursue Melanotan II as a treatment for erectile dysfunction and later to develop PT-141 (bremelanotide), a modified analog with improved side effect profile that received FDA approval for female sexual dysfunction in 2019

Conclusions: GLP-1RAs show promising effects in PsO and early-PsA may represent a potential treatment window for maximizing therapeutic effects based on immunometabolic rationale, although this concept requires validation in dedicated clinical studies

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