The copper ion component is essential for lysyl oxidase activity, an enzyme critical for collagen and elastin cross-linking
Furthermore, after reacting with GSH, the generated Mn2 + also functioned as an MRI contrast agent, endowing the nanosystem with diagnostic imaging capabilities
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doi:10.1189/jlb.0605340 Toborek M, Seelbach MJ, Rashid CS, Andrs IE, Chen L, Park M, Esser KA (2013) Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood-brain-barrier
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