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Beyond cellular senescence, FOXO4-DRI demonstrates promise in neuroprotection, muscle regeneration, and cardiovascular health, positioning it as a keystone compound in longevity medicine (5, 6, 7)

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Moreover, oxidative stress can enhance the expression of adhesion molecules and proteases, facilitating cancer cell detachment, invasion into surrounding tissues, and entry into the bloodstream [120]

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it means that when it does, it might be unrelated to the NR getting to these tissues in one piece, so to speak, and instead be because it is acting as a precursor for NAM