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Those not achieving adequate glycemic control after 3-4 months at the maximum tolerated dose may require additional glucose-lowering therapy

Additionally, GA exhibits potent antioxidant capacity, significantly increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum, thereby mitigating oxidative damage (Shi et al., 2021)

Always start at 2.5mg for 4 weeks

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Start slowly after beginning a new drug to assess side effects

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice