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Kumar, but semaglutide should still help with other symptoms, like sugar cravings, earlier on
The consistent theme is restraint: hold the per-dose amount steady, use frequency and cycle structure as the adjustable variables, and build in breaks
In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers
8 In part, its benefit is also derived from lower body weight allowing less stress on the joints
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Improvement is possible but not guaranteed
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