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Phase II clinical trials in humans showed that AOD-9604 produced statistically significant weight loss compared to placebo over 12 weeks

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

Neurological impact of vitamin B12 deficiency

If you have ongoing absorption problems or have had gastrointestinal surgery, you may need lifelong monthly injections

The answer is not simple

Safety and Considerations While B12 injections are generally safe, its important to receive them from qualified professionals