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The third pathway is proline utilisation which occurs in mitochondria where proline is oxidised to pyrroline-5-carboxylate by mitochondrial proline dehydrogenase ( PUT1 ) which, in turn, is further oxidised to glutamate by 1-pyrroline-5-caboxylate dehydrogenase ( PUT2 ) 19
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Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation
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