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In studies with rats and mice, Saxenda and medicines that work like Saxenda caused thyroid tumors, including thyroid cancer

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This triple-action mechanism distinguishes it from existing approved agents such as semaglutide (GLP-1 only) or tirzepatide (GLP-1/GIP dual agonist)

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A French study analyzing data from the national health insurance system found that current use of GLP-1 RAs was associated with a 46% increased risk of all thyroid cancers and a 78% increased risk of medullary thyroid cancer after one to three years of use

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