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However, the initial site of metformins action remains the gut, leading us to believe that the gastrointestinal tract is the primary target of metformins action

Besides their detrimental effects, ROS are inevitable participants of vital cellular functions and mild oxidative stress is necessary for inducing biological adaptive responses to cope with distress and maintaining redox equilibrium (Hong et al

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In a follow-up study, a calorie-restricted weight-matched group was introduced alongside the vehicle, GLP-1, MK-801 and GLP-1MK-801 groups (Extended Data Fig

& Rehman, M

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