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In a maintenance trial, nausea fell from 47% during escalation to 14% after the 2.4 mg dose was held. Are symptoms not listed on the semaglutide label still reported

Moreover, not all methodologies utilized in these studies are properly validated against the gold standard, i.e., the Ussing chamber, and therefore caution is needed in the interpretation of these permeability data

This hypothesis is supported by emerging data but has not been definitively confirmed in large trials

Muttenthaler, M., et al

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