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Given that GLP-1 drugs are more effective for weight loss, the main reason people are still interested in AOD-9604 is because of a 2015 study suggesting that it might help cartilage regeneration in osteoarthritic rabbits
Molecular mechanisms of action of steroid/thyroid receptor superfamily members
Evidence for the role of MCT1 in ketone uptake came from the observations that loss-of-function mutations in the SLC16A1 gene (which encodes the MCT1 protein) are associated with spontaneous ketoacidosis
doi: 10.1523/JNEUROSCI.2105-10.2010, 140 SticeE.YokumS.BohonC.MartiN.SmolenA
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