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Despite the definite clinical need for evidence-based treatments to correct problems with sleep and circadian rhythms, no well-designed studies on the efficacy of melatonin administration in sleep and circadian rhythms in bipolar disorder were identified [55]
K.GouinJ.-P.WengN.MalarkeyW
Determine the concentration of the controls and samples
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This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response
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