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HUBERMAN: And this is actually going to be a pretty quick discussion because really the main one in this category, besides thymus and beta-4, remember thymus and beta-4 we talked about earlier, this is a peptide that's naturally released from the thymus and the thymus is a structure that depletes over time as children age

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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

These effects are usually mild and transient