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Methods The current study is a multi-center observational cohort study was conducted simultaneously on December 2022, at 4 centers

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These improvements often create a positive cycle where increased energy enables more activity, which further improves fitness and energy capacity, leading to even more activity and better outcomes

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Gut microbiota contribute to MASLD development through various mechanisms, including disruption of liver choline metabolism (necessary for VLDL synthesis and liver lipid export) (150), alterations in bile acid synthesis (151, 152), ethanol production (153), and increased lipopolysaccharides (LPS), which results in liver inflammation (154156)

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#### Comparison summary table Side Effect Profile in Trials Reported side effects across all three compounds are dominated by gastrointestinal events [3][4][10]

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