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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

185 Gonullu, H

Like legumes, grains contain phytates, which bind to zinc and reduce its absorption (11)

Brain IRS2 signaling coordinates life span and nutrient homeostasis

Low levels of it can lead to severe health issues like cancer

Its especially important for older (35+ years old) patients trying to get pregnant to take vitamin E