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This dual action is one reason tirzepatide has generally produced greater average weight loss than semaglutide in several obesity-focused trials

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Inactive Components (Compounding Base) Because these are compounded medications, pharmacies may include additional base ingredients to prepare the injectable solution

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Hayley Miller, medical director of Nurx Weight Management, cautions that supplements tend to be "far more hype than evidence," and "any effect tends to be very modest and highly individual." Kumar shares a similar sentiment, saying that while some GLP-1 supplement ingredients have some research to suggest potential benefits, "the studies we have are generally small and short-term

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In one of the landmark studies that supported the use of this drug for weight loss, the individuals who were on the drug actually lost a meaningful amount of lean mass, not just fat mass

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