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As mentioned, DPP-4 inhibitors increase the concentration of endogenous GLP-1, leading to increased insulin secretion, decreased glucagon secretion, and decreased HbA1c in patients with T2DM
& van Raalte, D.H
Horm Metab Res (2017) 49:72331
Firstly, drug disposition with respect to both the drug's volume of distribution, the extent to which a drug is distributed throughout the body and the drug half-life, which quantifies its persistence
Sugihara E, Shimizu T, Kojima K, Ishizawa J, Andreeff M , Saya H
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