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Peptides are emerging as powerful tools for that purpose
The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)
Bibcode:1982JMBio.160..181T
It does this partly by shuttling electrons in what is called a redox reaction, moving between its two forms as it carries energy through metabolism
IGFBP-3 also increased. This endocrine response is central to tesamorelins research profile because the observed body-composition effects occur downstream of pituitary GH stimulation
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