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The study did conclude that exposure of human intestinal epithelium to sucralose-6-acetate as well as sucralose itself damaged tight junctions and impaired intestinal barrier function at mM concentrations. However, it is also important to note the direct exposure to intestinal cells occurred in the absence of intestinal bacteria, which does not perfectly replicate exposure to either compound in the body

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Melatonin and gestational hypertension [PMID: 34385689] Laboratory literature summary: Melatonin and gestational hypertension

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Statistical analysis For each study population, the semaglutide cohort and the comparision cohort were propensity-score matched (1:1 using nearest neighbor greedy matching with a caliper of 0.25 times the standard deviation) on covariates that are potential risk factors for AUD 57,58,59,60 including demographics, adverse socioeconomic determinants of health (e.g., problems related to education and literacy, employment and unemployment, housing and economic circumstances, social environment, upbringing, primary support group including family circumstances and various psychosocial circumstances), problems with lifestyle (e.g., tobacco use, lack of physical exercise, inappropriate diet and eating habits, high-risk sexual behavior, gambling and betting, and other problems related to lifestyle including antisocial behaviors and sleep deprivation), pre-existing medical conditions, medications, medical procedures and medical visit types (outpatient, inpatient, emergency, and virtual)