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Inflammatory and apoptotic pathways are modulated, including suppression of NF-B/TNF-/IL-6 and rebalancing of BAX/BCL-2 with reduced Caspase-3
Trimi correctly cites this as a 20% reduction in major heart events and appropriately attributes it to the SELECT trial and the specific FDA-approved Wegovy product and patient population
Rare but serious adverse effects include pancreatitis, gallbladder disease, hypersensitivity reactions (including anaphylaxis and angioedema), and, for Wegovy specifically, suicidal ideation
If leg cramps are mild and manageable, it may not be necessary to stop taking semaglutide
The future is in understanding the network, not just the nodes
