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Presented for research literature review only Marcovina SM et al
For topical applications targeting the scalp, the peptide must penetrate the stratum corneum to reach the dermal papilla at the base of each follicle
What is your body trying to tell you
Parent drug accumulated in plasma Greater hERG channel blockade Excessive QT prolongation The Fatal Outcome: Torsades de Pointes (TdP) Excessive QT prolongation predisposes the myocardium to early afterdepolarizations (EADs), which can rapidly progress to: Torsades de Pointes (TdP) Ventricular fibrillation Sudden cardiac death Key Pharmacovigilance Lesson A drug can be highly effective yet become life-threatening when metabolic pathways are disrupted
96 The primary end point (MI, stroke
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