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Precise measurements ensure research reproducibility across experiments

At the AMY 3 R, the RAMP3/CTR interface for the Cagri-bound AMY 3 R appears to be weaker than the rAmy-AMY 3 R where Y37 rAmy forms a H-bond interaction with E74 RAMP3 that stabilises the position of the ECD and the interface between the RAMP3 and CTR ECDs

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NCT04184622 ), and in SURPASS-2 it outperformed semaglutide on glucose and weight endpoints in type 2 diabetes ( Fras et al., NEJM 2021 )

Injections carry risks including nerve damage, kidney stress, allergic reactions, and in rare cases, liver abnormalities