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All wildtype and knockout mice used in our studies were in-house bred on a C57BL/6J background

It is different, however, in that it does not bind to IGFBPs

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Gremlin1 protein upregulation is attenuated in fibronectin conditional knockout lenses, which fail to either deposit fibrotic ECM or sustain canonical TGF signaling PLI, while the injury-induced fibrotic response (including TGF signaling) is restored in fibronectin null lenses treated with exogeneous Gremlin 1 (185)