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Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration
Mechanistic tool in preclinical work: Used to explore lipid and glucose metabolism pathways in controlled models of energy balance
Researchers can pharmacologically dissect these pathways using LY294002 (PI3K inhibitor) or U0126 (MEK inhibitor) to determine which downstream arm mediates a specific IGF-1 LR3 effect in their experimental system
*Correspondence: Zhenwei Mao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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