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Classically, after ingestion of certain agents like sulfamides, antipyretics, nitrofurans and antimalarial medicines, like the primaquine and chloroquine, the patient develops fever, black color urine, ictericia and anemia

It is generally considered safe when prescribed and monitored by a qualified healthcare professional

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In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate

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