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Finally, to determine whether RPS15 mutation also influences mRNA translation in leukemic B cells, and whether TP53 deletion impacts this relationship, we performed ribosome profiling concurrently in RPS15 -S138F mutant and WT HG3 cells with and without TP53 ( TP53 WT and TP53 KO , respectively)
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Published phase 2 data provide preliminary signals regarding tolerability in research cohorts, but these are not sufficient to establish a safety profile adequate for approved use
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