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Dermatol Surg 30:301310 Scherer D, Nagore E, Bermejo JL, Figl A, Botella-Estrada R, Thirumaran RK, Angelini S, Hemminki K, Schadendorf D, Kumar R (2009) Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations
Additional toxic mechanisms include ionic mimicry and structural disruption, such as Pb interfering with neuronal signal transduction via calcium substitution, and Hg causing irreversible inactivation of key metabolic enzymes through binding to thiol groups (Jaishankar et al
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Int J Mol Sci 21(20):7513
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