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Stay hydrated and avoid heavy or fatty foods during the initial treatment period
Vedolizumabs mechanism involves selective inhibition of 47-MAdCAM-1 binding to prevent gut-homing of lymphocytes while preserving systemic immunity as demonstrated by maintained humoral responses to parenteral vaccines but blocked responses to oral vaccines, with proposed effects on nave T and B cell trafficking to intestinal inductive sites and attenuation of lymphoid aggregates contributing to therapeutic benefit beyond simple effector cell blockade
Accepted: May 11, 2018
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