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Phase 1 studies in healthy volunteers demonstrated acceptable safety and tolerability

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FDAs October 2024 PCAC briefing document is the most authoritative summary of available evidence

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This is the formation of new blood vessels

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Subcutaneous and intraperitoneal routes give shorter circulating windows, with the compound clearing primarily through proteolytic degradation outside the GI tract rather than through renal or hepatic elimination as a single molecule

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