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Heintjes EM, Houben E, Beekman-Hendriks WL, et al
The global semaglutide market (Ozempic, Wegovy, Rybelsus and others) was worth about 2829 billion USD in 2024 alone .[16][17][18] Market analysts project it could reach around 9094 billion USD per year by 2035 in a basecase scenario.[15][18][16] Given these annual numbers, cumulative worldwide sales from launch (2017) to now easily run into many tens of billions of dollars , and over its full commercial life semaglutide is on track to become one of the most lucrative drug franchises in history.[17][18][15] Key point: Semaglutide is not just a blockbuster
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We observed significant variability in the thoroughness of clinical evaluations
Higher concentrations may offer some stability advantages in certain formulations because the peptide-to-surface ratio is more favorable, but they can also increase the risk of aggregation if the formulation is not optimized for that concentration
Clinical implications of the SURMOUNT program While modest WL (510%) is clinically meaningful for people with overweight and obesity, greater and sustained WL (10% and ideally 15% WL) may be required to achieve improvements or remission of certain obesity-related complications such as T2D, HFpEF, MASH, OSA and knee osteoarthritis, as well as to improve QoL and reduce the risk for cardiovascular events [Citation3,Citation70,Citation71]
