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During daily wound care, TCC-treated wounds initially presented with a bluish film and, on days 2-3, developed a tenacious, purulent-appearing exudate

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The second study with 426 patients randomly assigned to TAK-875, placebo, or glimepiride treatment groups showed significant reductions in HbA1c levels from baseline in the TAK-875 (6.25 to 50 mg) and glimepiride (4 mg) treatment groups compared with the placebo group at week 12 [60]

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It is known as GlyNAC

They're not necessarily indicators of intolerance but rather evidence of pharmacological activity