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injection, GGsTop (Tocris, 4452
The primary function of the HSD11B1 encoded enzyme is to reduce the 11-oxo groups in cortisone and 11-dehydrocorticosterone to the active glucocorticoids, cortisol and corticosterone, respectively
The latter being the most important for adipose tissue remodelling
The inconclusive results represent an important controversy in this area
However, practically, it is almost impossible to develop a synthetic mimic having catalytic efficiency similar to that of a native enzyme
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