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With over 50 million individuals currently affected by dementia worldwidea number projected to double by 2050there is a critical need for novel, mechanism-based interventions, particularly in the absence of curative therapies (Sexton et al., 2022)

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For electrophysiological studies, male pathogen-free mice at an age of 618 weeks were used for all experiments

(3) diverse patient populations with varying background medication regimens, comorbidity burdens (obesity, cardiovascular disease, NAFLD, chronic kidney disease), and baseline inflammatory states