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These neurons either express the neurotransmitter norepinephrine (NE) or the neuropeptide CCK and are monosynaptically connected to calcitonin generegulated peptide (CGRP)-expressing neurons in the lateral parabrachial nucleus (lPBN) of the pons [61], which are in turn monosynaptically connected to protein kinase C (PKC)-delta-expressing neurons in the central nucleus of the amygdala (CeA) in the forebrain [62, 63], thus forming a tripartite functional unit

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