In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]
All of these processes tend to initiate ferroptosis, leading to cell damage [22]
Applied Physiology, Nutrition, and Metabolism
The Heavy Hitters: GLP-1 Receptor Agonists If lowering A1C was a race, GLP-1 receptor agonists are currently injectable medications that mimic the incretin hormone GLP-1 to stimulate insulin release, slow digestion, and reduce appetite
The product should be taken as directed on the packaging or by a health professional
These are usually manageable but should be monitored