368 Recent studies further reveal that the mitophagy receptor NLRX1 is directly regulated by the metabolic signal cytosolic acetyl-coenzyme A (AcCoA) and mediates resistance to KRAS inhibitors, offering a novel molecular framework and actionable vulnerability for overcoming targeted therapy resistance
Tribble JR, Otmani A, Kokkali E, Lardner E, Morgan JE, Williams PA
Gene expression analysis revealed no changes in HIF-1 mRNA, suggesting that GLP-1R signalling induces HIF-1 protein by a post-transcriptional mechanism (Fig
Mojsov quickly recognized that her Bpoc/Wang resin approach, having achieved the seemingly impossible in enabling an SPPS synthesis at all, would not meet these further requirements
Research also suggests that some of the metabolic and cardiovascular benefits gained during treatment may diminish once medication stops
The landscape is actively changing