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Another metabolically relevant compound that links carnitine and CoA derivatives is the malonyl-CoA that is required for fatty acid biosynthesis but acts as a potent inhibitor of the carnitine acyltransferases using cytoplasmic substrates, such as carnitine palmitoyltransferase 1 (CPT1), which is the first component of the mitochondrial carnitine shuttle (Ramsay and Arduini, 1993)
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122 (12), e2416162122
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doi: 10.1136/thoraxjnl-2015-207052 188 AdewoleOOOmotosoBAOgunsinaMAminuAOdeyemiAOAwopejuOFet al
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