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Regulatory agencies increasingly recognize the value of surrogate endpoints, adaptive trial designs, and biomarker-driven patient stratification, particularly in areas of high unmet need
"Its an opportunity
Romero et al, 2017
Connection between gut microbiome and the development of obesity
The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively
doi:10.2174/1570161117666190621150725 Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA
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