A practical severity estimate based on the available preclinical signals: Serotonergic risk : Low-to-moderate plausibility based on rodent monoamine modulation data, but direction of effect (agonism vs
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A: Milk thistle supports liver function, provides antioxidant protection, reduces inflammation, and may improve digestive health
Risks and Safety Considerations to Discuss With Your Doctor Key risks include cardiovascular effects from both agents, hormonal fluctuations due to rapid weight loss altering SHBG and free testosterone, gastrointestinal side effects, and the unknown combined safety profile of an unlicensed drug alongside a controlled hormone therapy
Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M