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Semaglutide, available in oral and subcutaneous formulations, is a notable member of this class

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Less common effects to keep an eye on Less often, people experience prolonged bruising over one to two weeks, hyperpigmentation (temporary darkening of the treated skin), or, rarely, a localised infection

In 1987, Kreymann et al

Glucagon enhances multiple steps in this pathway: Increased lipolysis: Glucagon activates hormone-sensitive lipase in adipose tissue, releasing more fatty acids into circulation Reduced lipogenesis: Glucagon suppresses the enzymes responsible for creating new fat from carbohydrates Enhanced hepatic oxidation: Glucagon upregulates liver enzymes involved in fatty acid oxidation Ketogenesis: When fat oxidation exceeds the citric acid cycle capacity, excess acetyl-CoA is converted to ketone bodies, an alternative fuel source The net effect is a metabolic state favoring fat breakdown over fat storage

Injection site reactions, including redness, bruising, or mild swelling, were also reported but were generally transient