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Realistic expectations regarding weight loss magnitude (typically 10-15% of body weight with higher-dose formulations) and the importance of concurrent lifestyle modification should be established before initiating therapy

Develop, demonstrate, and disseminate learning modules for school personnel (teachers, coaches), parents, school-aged children, and primary care pediatricians and child mental health professionals about the GL1-RA medications, their appropriate uses and possible abuse

Together, they create a more stable, sustainable environment for healthy weight management

All GCT enzymes possess a highly conserved pocket, proposed to be the active site, which contains a catalytically relevant glutamate residue

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