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From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies

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While often mild and self-limiting, it causes some users to discontinue therapy or struggle with dose escalation

AOD-9604 AOD-9604 (Advanced Obesity Drug) is a modified fragment of the human Growth Hormone (GH) molecule specifically the last 15 amino acids of the GH sequence scientifically designed to target and regulate fat metabolism without influencing blood sugar or growth hormone levels

19 Yazaki, Y., Chow, G