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Hormonal changes during perimenopause and menopause influence insulin sensitivity, appetite regulation, and medication tolerance

Patients with a specific form of familial hypercholesterolemia not due to mutations in the LDLR gene were shown to have severe hypercholesterolemia due to mutations in the PCSK9 gene resulting in hyperactivity (gain-of-function mutations) of the enzyme

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The delayed gastric emptying characteristic of these therapies frequently causes gastrointestinal adverse effects, particularly nausea, vomiting, and diarrhea

Queval et al., 2009

Animal data indicates rapid clearance typical of unmodified small peptides, generally minutes to low hours in plasma