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In research settings, Melanotan II is of interest due to its interaction with melanocortin receptors, particularly pathways associated with melanin production, pigmentation biology, cellular response to UV exposure, and broader melanocortin system activity

Table 22.1 summarizes clinical considerations for CMN

There are three different UPR signaling pathways in ERS response that are mediated by (1) RNA-dependent protein kinase-like ER kinase (PERK), (2) activated transcription factor 6 (ATF6), and (3) inositol-required enzyme 1 (IRE1) (69)

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crassa SHMT that was used in this study (Schirch et al., 1985)