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[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism
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Some experts, in considering the need for treatment, also assess the intensity of liver inflammation
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The potential success of this approach is enhanced given that GIP, GLP-1, and GLP-2 based drugs are already in clinical use, although postulated benefits on bone health still need to be fully confirmed ( Figure 3 )
