Our observations about the efficacy of GLP-1 RAs in enhancing survival and reducing cardiovascular events are concordance with evidence from several cardiovascular outcome trials (CVOTs) conducted in general population with T2DM, as well as a recent cohort study focused on solid organ transplant recipients [16,17,18,19, 23]
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Tirzepatide is not recommended during pregnancy or breastfeeding, and women planning pregnancy should discuss discontinuation timing with their healthcare provider
Hepatocyte depletion of ERK5 in vivo was also associated with reduced expression of IR, and increased expression of PGC-1 and TRIB3
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