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However, prolonged high doses of vitamin B12 can lead to various side effects: Anaphylactic shock: This allergic reaction to vitamin B12 is rare but very dangerous, potentially leading to death

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But an association seen in groups of patients is a long way from a prediction about any one person, and the authors note that the causes of a high B12 are multiple and its consequences not clearly established

The PK-PD disconnect why short half-life doesnt limit efficacy The striking feature of BPC-157 research is the disparity between short serum presence and sustained tissue-level effects