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This creates a biological ceiling that cannot be overcome by simply adding more input

3,417 adults with overweight or obesity but without type 2 diabetes

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The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)