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Dr John Eng and his colleagues discovered a peptide in the venom called exendin-4 , which shared structural similarities with human GLP-1 but possessed a crucial advantage: it was resistant to breakdown by DPP-4
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Once the primary visceral (intra-abdominal) fat depots are saturated, free fatty acid spillover into non-adipose tissues and begin to accumulate in ectopic fat depots (liver, skeletal muscle, heart, pancreas, kidney, bone marrow, and central nervous system (CNS) which leads to lipotoxicity, inflammation, and ultimately B-cell dysfunction [64,65,66,67,68,69,70,71]
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